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Title: | Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media |
Authors: | Gozeler, M. S. Halici, Z. Korkmaz, H. Korkmaz, M. Mutlu, V. Selli, J. Tatar, A. Uslu, H. Yayla, M. Ordu Üniversitesi 0000-0002-0659-3084 0000-0002-0988-4354 |
Keywords: | NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; MIDDLE-EAR; TISSUE-DAMAGE; CELLS; RATS; EXPRESSION; INDUCTION; EFFUSION; CHILDREN Otitis Media; Reactive Oxygen Species; Alpha-Lipoic Acid; Inflammation; Guinea Pig |
Issue Date: | 2016 |
Publisher: | CAMBRIDGE UNIV PRESS, EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND |
Abstract: | Objectives: To investigate the anti-inflammatory, anti-oxidative and tissue protective effects, as well as the potential therapeutic role, of alpha-lipoic acid in experimentally induced acute otitis media. Methods: Twenty-five guinea pigs were assigned to one of five groups: a control (non-otitis) group, and otitis-induced groups treated with saline, penicillin G, alpha-lipoic acid, or alpha-lipoic acid plus penicillin G. Tissue samples were histologically analysed, and oxidative parameters in tissue samples were measured and compared between groups. Results: The epithelial integrity was better preserved, and histological signs of inflammation and secretory metaplasia were decreased, in all groups compared to the saline treated otitis group. In the alpha-lipoic acid plus penicillin G treated otitis group, epithelial integrity was well preserved and histological findings of inflammation were significantly decreased compared to the saline, penicillin G and alpha-lipoic acid treated otitis groups. The most favourable oxidative parameters were observed in the control group, followed by the alpha-lipoic acid plus penicillin G treated otitis group. Conclusion: Alpha-lipoic acid, with its antioxidant, anti-inflammatory and tissue protective properties, may decrease the clinical sequelae and morbidity associated with acute otitis media. |
URI: | http://doi.org/10.1017/S0022215116001183 https://www.cambridge.org/core/journals/journal-of-laryngology-and-otology/article/antiinflammatory-and-antioxidative-effects-of-alphalipoic-acid-in-experimentally-induced-acute-otitis-media/EEB544564AE23412899455783D031FF0 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2628 |
Appears in Collections: | Cerrahi Tıp Bilimleri |
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