Please use this identifier to cite or link to this item:
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2627
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alemdar, Celil | - |
dc.contributor.author | Atic, Ramazan | - |
dc.contributor.author | Erbil, Baris | - |
dc.contributor.author | Erdem, Havva | - |
dc.contributor.author | Ozkul, Emin | - |
dc.contributor.author | Yucel, Istemi | - |
dc.date.accessioned | 2022-08-17T06:55:44Z | - |
dc.date.available | 2022-08-17T06:55:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://doi.org/10.4103/0019-5413.185607 | - |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/27512224/ | - |
dc.identifier.uri | http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2627 | - |
dc.description.abstract | Background: The common purpose of almost all methods used to treat the osteochondral injuries is to produce a normal cartilage matrix. However current methods are not sufficient to provide a normal cartilage matrix. For that reason, researchers have studied to increase the effectiveness of this methods using chondrogenic and chondroprotective molecules in recent experimental studies. Insulin-like growth factor-1 (IGF-1) and hyaluronic acid (HA) are two important agents used in this field. This study compared the effects of IGF-1 and HA in an experimental osteochondral defect in rat femora. Materials and Methods: The rats were divided into three groups ( n = 15 per group) as follows: The IGF-1 group, HA group, and control group. An osteochondral defect of a diameter of 1.5 mm and a depth of 2 mm was created on the patellar joint side of femoral condyles. The IGF-1 group received an absorbable gelatin sponge soaked with 15 g/15 l of IGF-1, and the HA group received an absorbable gelatin sponge soaked with 80 g HA. The control group received only an absorbable gelatin sponge. Rats were sacrificed at the 6 (th) week, and the femur condyles were evaluated histologically. Results: According to the total Mankin scale, there was a statistically significant difference between IGF-1 and HA groups and between IGF-1 and control groups. There was also a significant statistical difference between HA and control groups. Conclusion: It was shown histopathologically that IGF-1 is an effective molecule for osteochondral lesions. Although it is weaker than IGF-1, HA also strengthened the repair tissue. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MEDKNOW PUBLICATIONS & MEDIA PVT LTD, B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA | en_US |
dc.relation.isversionof | 10.4103/0019-5413.185607 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | ARTICULAR-CARTILAGE REPAIR; KNEE; OSTEOARTHRITIS; LESIONS; TISSUE; CELLS; TALUS | en_US |
dc.subject | Cartilage; hyaluronic acid; insulin-like growth factor-1; osteochondral defect MeSH terms: Hyaluronic acid; cartilage; IGF-1; sports medicine; rats | en_US |
dc.title | Effect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | INDIAN JOURNAL OF ORTHOPAEDICS | en_US |
dc.contributor.department | Ordu Üniversitesi | en_US |
dc.contributor.authorID | 0000-0002-3074-0240 | en_US |
dc.contributor.authorID | 0000-0003-2149-8154 | en_US |
dc.identifier.volume | 50 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 414 | en_US |
dc.identifier.endpage | 420 | en_US |
Appears in Collections: | Cerrahi Tıp Bilimleri |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.