Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2588
Title: Anticancer activities of manganese-based photoactivatable CO-releasing complexes (PhotoCORMs) with benzimidazole derivative ligands
Authors: Coskun, Kubra A.
Dusunceli, Serpil Demir
Ozdemir, Ismail
Ozgur, Aykut
Tutar, Yusuf
Ustun, Elvan
Ordu Üniversitesi
0000-0001-6325-0216
0000-0001-8765-4039
0000-0002-0587-7261
0000-0003-2613-9644
Keywords: HEME OXYGENASE-1; CARBON-MONOXIDE; ZINC PROTOPORPHYRIN; NITRIC-OXIDE; CANCER-CELLS; TUMOR-CELLS; INHIBITION; OVEREXPRESSION; PROLIFERATION; CYTOTOXICITY
Issue Date: 2017
Publisher: SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
Abstract: Carbon monoxide is an important signaling molecule which is produced by heme oxygenase-1. CO shows antiproliferative activity against cancer cells; hence, activation of HO-1 is a significant inhibition strategy against tumor formation and survival of cancer cells. In this work, manganese-based CO-releasing molecules (CORMs) were designed and synthesized to inhibit breast cancer cell proliferation. Human invasive ductal breast cancer cells (MCF-7) were treated with the synthesized CORMs to investigate the effect of the complexes on breast cancer survival under UV light. In vitro experiments indicated that the complexes inhibited breast cancer cell proliferation, and further, the antiproliferative effects were increased under UV light. Thus, these novel CORMs may provide a drug template for the treatment of invasive ductal breast cancer.
URI: http://doi.org/10.1007/s11243-017-0136-x
https://link.springer.com/article/10.1007%2Fs11243-017-0136-x
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2588
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