Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2582
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dc.contributor.authorAtici, Yunus-
dc.contributor.authorBengu, Aydin Sukru-
dc.contributor.authorCirakli, Alper-
dc.contributor.authorDemiroz, Serdar-
dc.contributor.authorErdem, Sevki-
dc.contributor.authorErdogan, Sinan-
dc.contributor.authorUlucan, Aykut-
dc.contributor.authorUr, Koray-
dc.date.accessioned2022-08-17T06:48:09Z-
dc.date.available2022-08-17T06:48:09Z-
dc.date.issued2020-
dc.identifier.urihttp://doi.org/10.3340/jkns.2019.0178-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2582-
dc.description.abstractObjective : To evaluate the neuroprotective effects of lacosamide after experimental peripheral nerve injury in rats. Methods : A total of 28 male wistar albino rats weighing 300-350 g were divided into four groups. In group I, the sciatic nerve exposed and the surgical wound was closed without injury; in group II, peripheral nerve injuries (PNI) was performed after dissection of the nerve; in group III, PNI was performed after dissection and lacosamide was administered, and in group IV, PNI was performed after dissection and physiological saline solution was administered. At 7 days after the injury all animals were sacrificed after walking track analysis. A 5 mL blood sample was drawn for biochemical analysis, and sciatic nerve tissues were removed for histopathological examination. Results : There is low tissue damage in lacosamide treated group and antioxidant anzymes and malondialdehyde levels were higher than non-treated and placebo treated group. However there was no improvement on clinical assessment. Conclusion : The biochemical and histological analyses revealed that lacosamide has neuroprotective effect in PNI in rats. This neuroprotective capacity depends on its scavenger role for free oxygen radicals by increasing antioxidant enzyme activity.en_US
dc.language.isoengen_US
dc.publisherKOREAN NEUROSURGICAL SOC, BLDG B, #402, 27, CHILPAE-RO, JUNG-GU, SEOUL, 04511, SOUTH KOREAen_US
dc.relation.isversionof10.3340/jkns.2019.0178en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLacosamide; Peripheral nerve injuries; Sciatic nerveen_US
dc.subjectSPINAL-CORD-INJURY; AXONAL REGENERATION; FUNCTIONAL RECOVERY; LIPID-PEROXIDATION; MODEL; ACIDen_US
dc.titleNeuroprotective Effects of Lacosamide in Experimental Peripheral Nerve Injury in Rats : A Prospective Randomized and Placebo-Controlled Trialen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF KOREAN NEUROSURGICAL SOCIETYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-3977-3380en_US
dc.contributor.authorID0000-0002-7635-4855en_US
dc.contributor.authorID0000-0002-8517-3925en_US
dc.identifier.volume63en_US
dc.identifier.issue2en_US
dc.identifier.startpage171en_US
dc.identifier.endpage177en_US
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