Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2530
Title: Static magnetic field inhibits 5 ' nucleotidase activity in cancerous and non-cancerous human gastric tissues
Authors: Buber, Suleyman
Durak, Zahide Esra
Kocaoglu, Ender Hilmi
Ozturk, Bahadir
Ordu Üniversitesi
0000-0001-6831-0070
0000-0003-2654-7621
Keywords: ADENOSINE-DEAMINASE; SUPEROXIDE-DISMUTASE; CATALASE ACTIVITIES; XANTHINE-OXIDASE; IN-VIVO; TUMOR-GROWTH; CELLS; ANGIOGENESIS; CARCINOMA; CISPLATIN
Cancer; 5 nucleotidase; static magnetic field; xanthine oxidase
Issue Date: 2016
Publisher: TAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
Abstract: The aim of the present study is to investigate possible effects of static magnetic field (SMF) on 5 nucleotidase (5NT-CD73) and xanthine oxidase (XO) activities in cancerous and non-cancerous human gastric tissues in order to contribute to the elucidation of the anticancer activity of SMF. Cancerous and non-cancerous human gastric tissues removed from patients by surgical operations were used in the studies. SMF was created using two static magnets. Before and after treatment with SMF, 5NT and XO activities in the tissue samples were measured. 5NT activity was found to be lowered, but no significant change was observed in XO activity in the gastric tissues treated with the SMF. Our results suggest that SMF inhibits 5NT enzyme in gastric tissues significantly. It is supposed that in addition to other proposed mechanisms, inhibition of purine catabolic activity due to inhibition of some key enzymes in the DNA turn-over like 5NT might also play part in the anticancer activity of SMF.
URI: http://doi.org/10.3109/15368378.2014.977389
https://www.tandfonline.com/doi/full/10.3109/15368378.2014.977389
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2530
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