Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2524
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dc.contributor.authorBillur, D.-
dc.contributor.authorDurak, I-
dc.contributor.authorDurak, Z. E.-
dc.contributor.authorKizil, S.-
dc.contributor.authorOzer, O.-
dc.contributor.authorOzturk, B.-
dc.contributor.authorOzturk, H. S.-
dc.date.accessioned2022-08-17T06:40:22Z-
dc.date.available2022-08-17T06:40:22Z-
dc.date.issued2016-
dc.identifier.urihttp://doi.org/10.4149/BLL_2016_045-
dc.identifier.urihttp://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=4746&category_id=129&option=com_virtuemart&vmcchk=1&Itemid=1-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2524-
dc.description.abstractOBJECTIVES: The aim of this study was to investigate possible effects of high cholesterol diet on oxidant/antioxidant status in rabbit kidney tissues. BACKGROUND:Although a number of experimental animal models have suggested that hyperlipidemia is associated with progressive kidney failure data remain sparse on the role of dietary cholesterol intake on kidney disease. METHODS: Twelve male New Zealand albino rabbits were randomly divided into two groups (control and cholesterol). Both groups were fed on a standard laboratory diet. Animals in the cholesterol group additionally received cholesterol (1 g/kg/day), orally. The study period was 12 weeks. Activities of catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), nitric oxide synthase (NOS), xanthine oxidase (XO), paraoxonase (PON), adenosine deaminase (ADA) enzymes and levels of malondialdehyde (MDA) and nitric oxide (NO) were measured in kidney tissue samples. Histological examination of the kidney tissue samples was also done. RESULTS: SOD, GSH-Px and XO enzyme activities were found to be decreased and NOS and PON activities increased significantly in cholesterol group compared to controls. As an indication of oxidation, MDA levels were found to be increased in cholesterol group. Histological examination revealed some derangements in the kidney tissue. CONCLUSION: High cholesterol diet creates oxidant load and causes peroxidation, which in turn, leads derangements in the rabbit kidney tissue (Tab. 2, Fig. 2, Ref. 69). Text in PDF www.elis.sk.en_US
dc.language.isoengen_US
dc.publisherCOMENIUS UNIV, SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIAen_US
dc.relation.isversionof10.4149/BLL_2016_045en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcholesterol; oxidant / antioxidant system; kidney; rabbiten_US
dc.titleHigh cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissueen_US
dc.typearticleen_US
dc.relation.journalBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-6831-0070en_US
dc.contributor.authorID0000-0001-8356-9224en_US
dc.contributor.authorID0000-0001-8541-8251en_US
dc.contributor.authorID0000-0002-0616-1935en_US
dc.contributor.authorID0000-0003-2654-7621en_US
dc.identifier.volume117en_US
dc.identifier.issue4en_US
dc.identifier.startpage235en_US
dc.identifier.endpage241en_US
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