Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2497
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dc.contributor.authorBuber, Suleyman-
dc.contributor.authorDevrim, Erdinc-
dc.contributor.authorDurak, Ilker-
dc.contributor.authorDurak, Zahide Esra-
dc.contributor.authorKocaoglu, Hilmi-
dc.date.accessioned2022-08-17T06:25:42Z-
dc.date.available2022-08-17T06:25:42Z-
dc.date.issued2014-
dc.identifier.urihttp://doi.org/10.4103/0973-1296.133232-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2497-
dc.description.abstractObjective: To investigate possible effects of aqueous taxus baccata extract on adenosine deaminase (ADA) activity in cancerous and noncancerous human tissues and to clarify mechanism(s) of its anticancer potential. Materials and Methods: Cancerous and noncancerous human gastric and colon tissues were used in the study. The extracts were prepared in distilled water. Before and after treatment with the extracts, ADA activities in the tissue homogenates were measured. Results: ADA activity was found to be higher in gastric tissue compared with colon tissue, but no differences were found between ADA activities of cancerous and noncancerous tissues for both as well. In the plant extract studies, it was found that taxus extract significantly inhibited ADA activity both in cancerous and noncancerous gastric and colon tissues. Conclusion: Our results suggest that aqueous extract from taxus baccata inhibits ADA activities in both gastric and colon tissues significantly. It is suggested that in addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA enzyme might also play part in the anticancer properties of taxus species.en_US
dc.language.isoengen_US
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONSWOLTERS KLUWER INDIA PVT LTD, A-202, 2ND FLR, QUBE, C T S NO 1498A-2 VILLAGE MAROL, ANDHERI EAST, MUMBAI 400059, INDIAen_US
dc.relation.isversionof10.4103/0973-1296.133232en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenosine deaminase cancer taxol taxus baccataen_US
dc.subjectVINCA ALKAL OID SAGENT SPLANT SPACLI TAXEL TAXANES TAXOLen_US
dc.titleAqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissuesen_US
dc.typearticleen_US
dc.relation.journalPHARMACOGNOSY MAGAZINEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-6831-0070en_US
dc.contributor.authorID0000-0001-7326-5104en_US
dc.identifier.volume10en_US
dc.identifier.issue38en_US
dc.identifier.startpage214en_US
dc.identifier.endpage216en_US
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