Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2462
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dc.contributor.authorEnginyurt, Ozgur-
dc.contributor.authorGunaydin, Zeki Yuksel-
dc.contributor.authorKaya, Ahmet-
dc.contributor.authorKaya, Yasemin-
dc.contributor.authorPolat, Yavuz Kursat-
dc.contributor.authorSaritemur, Murat-
dc.contributor.authorTopcu, Selim-
dc.date.accessioned2022-08-17T05:58:36Z-
dc.date.available2022-08-17T05:58:36Z-
dc.date.issued2014-
dc.identifier.urihttp://doi.org/10.5152/eajm.2014.22-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2462-
dc.description.abstractObjective: Increased serum gamma-glutamyl transferase levels (GGT) have been shown to directly promote oxidative stress. Previous studies have shown the relationship between the dilatation of the ascending aorta and oxidative stress. This study was designed to examine the relationship between serum GGT concentrations with dilatation of the ascending aorta. Materials and Methods: Ninety patients with ascending aortic dilatation and 90 age-sex-matched patients without aortic dilatation were included in the study. The patients were evaluated by a complete transthoracic echocardiographic examination including measurement of the aortic dimensions, where a diameter of 3.7 cm and above was accepted as ascending aortic dilatation. Serum GGT concentration was measured in all patients. Results: In the group with aortic dilatation, HT frequency, serum uric acid, hs-CRP and GGT levels, the LV mass index, and the left atrial volume index were found to be higher than the control group. The logistic regression analysis showed that only HT frequency (OR: 1.23, 95% CI 1.11-1.35, p value: 0.02), the LA volume index (OR: 1.34, 95% CI 1.21 +/- 1.4, p:0.005) and serum GGT levels (OR: 1.12, 95% CI 1.01 +/- 1.20, p:0.03) were found to be independent predictors. There was a significant correlation between serum GGT levels and ascending aortic diameter (r: 0.268, p<0.001). In the ROC curve analysis, AUC was 0.659 (0.580 +/- 0.738) for a 23.5 serum GGT cut-off value (64% sensitivity and 53% specificity). Conclusion: We found that serum GGT concentration was significantly associated with ascending aortic dilatation. Large epidemiological studies are required to correlate the findings from this study with clinical outcome.en_US
dc.language.isoengen_US
dc.publisherAVESBUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEYen_US
dc.relation.isversionof10.5152/eajm.2014.22en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGamma-glutamyl transferaseaortic dilatationoxidative stresen_US
dc.titleRelationship between Serum Gamma-glutamyl Transferase Levels with Ascending Aortic Dilatationen_US
dc.typearticleen_US
dc.relation.journalEURASIAN JOURNAL OF MEDICINEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-9779-7578en_US
dc.contributor.authorID0000-0001-9845-7938en_US
dc.contributor.authorID0000-0002-4601-1341en_US
dc.identifier.volume46en_US
dc.identifier.issue2en_US
dc.identifier.startpage89en_US
dc.identifier.endpage95en_US
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