Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2442
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dc.contributor.authorAdanur, Senol-
dc.contributor.authorAlp, Hamit H.-
dc.contributor.authorArslan, Aynur-
dc.contributor.authorKunak, Celalettin S.-
dc.contributor.authorSuleyman, Bahadir-
dc.contributor.authorYapanoglu, Turgut-
dc.contributor.authorZiypak, Tevfik-
dc.date.accessioned2022-08-17T05:54:47Z-
dc.date.available2022-08-17T05:54:47Z-
dc.date.issued2015-
dc.identifier.urihttp://www.latamjpharm.org/resumenes/34/5/LAJOP_34_5_1_16.pdf-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2442-
dc.description.abstractIn this study, the effects of resveratrol were investigated on paracetamol-induced oxidative kidney damage in rats and compared with N-acetylcysteine (NAC). Rats were divided into healthy (HG), paracetamol control (PAC), resveratrol + paracetamol (RPA), NAC + paracetamol (NPA) groups. RPA group was administered 30 mg/kg resveratrol, NPA group was administered NAC in 300 mg/kg doses. Distilled water was administered to HG and PAC group. One hour after administration of the drugs and distilled water, all groups (except for HG) were given paracetamol 1000 mg/kg dose. 24 h after paracetamol administration, animals were killed by anesthesia and their kidneys were removed. Biochemical investigations were carried out on the kidneys. Resveratrol and NAC almost equally suppressed the increase of malondialdehyde (MDA) amount in the renal tissue of paracetamol-administered group. But resveratrol reduced the increase of 8-hydroxyguanine (8-OHGua), creatinine and blood urea nitrogen (BUN) more significantly than NAC. Resveratrol prevented loss of total glutathione (tGSH) in rats taking paracetamol better than NAC. As a result, resveratrol was determined to prevent oxidative renal damage and functional disorder related to paracetamol better than NAC.en_US
dc.language.isoengen_US
dc.publisherCOLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRESDEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA 00000, ARGENTINAen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacetylcysteineparacetamolratresveratrolen_US
dc.subjectDNA-DAMAGEELECTROCHEMICAL DETECTIONINDUCED NEPHROTOXICITYRENAL-FAILUREACETAMINOPHENSTRESSRATSHEPATOTOXICITYMETHOTREXATE8-OXOGUANINEen_US
dc.titleThe Comparison of Resveratrol and N-Acetylcysteine on the Oxidative Kidney Damage Caused by High Dose Paracetamolen_US
dc.typearticleen_US
dc.relation.journalLATIN AMERICAN JOURNAL OF PHARMACYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-5968-5823en_US
dc.contributor.authorID0000-0003-2231-3967en_US
dc.identifier.volume34en_US
dc.identifier.issue5en_US
dc.identifier.startpage973en_US
dc.identifier.endpage979en_US
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