Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2438
Title: What is the role of bosentan in healing of femur fractures in a rat model?
Authors: Akpinar, Erol
Aksakal, A. Murat
Atmaca, H. Tarik
Aydin, Ali
Cadirci, Elif
Halici, Zekai
Karcioglu, S. Sena
Kunak, C. Semih
Saritemur, Murat
Yayla, Muhammed
Ordu Üniversitesi
0000-0001-8379-4114
0000-0002-0659-3084
0000-0003-0836-7205
0000-0003-2231-3967
Keywords: BosentanEndothelin 1Bone fractureRatFemur
TUMOR-NECROSIS-FACTORRESISTANT PROSTATE-CANCERENDOTHELIAL GROWTH-FACTORPOSTMENOPAUSAL WOMENBONE-RESORPTIONVASCULAR CONTRIBUTIONSIGNAL-TRANSDUCTIONGENE-EXPRESSIONIN-VITROOSTEOBLASTS
Issue Date: 2015
Publisher: SPRINGER JAPAN KKSHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO 105-6005, JAPAN
Abstract: The purpose of this study was to examine the effects bosentan (which is a strong vasoconstrictor) on bone fracture pathophysiology, and investigate the roles of the nonselective endothelin 1 receptor blocker bosentan on the bone fractures formed in rats through radiographic, histopathologic, and immunohistochemical methods. The rats were divided into three groups (six rats in each group): a femoral fracture control group, a femoral fracture plus bosentan at 50 mg/kg group, and a femoral fracture plus bosentan at 100 mg/kg group. The femoral fracture model was established by transversely cutting the femur at the midsection. After manual reduction, the fractured femur was fixed with intramedullary Kirschner wires. The radiographic healing scores of the bosentan 100 and 50 mg/kg groups were significantly better that those of the fracture control group. The fracture callus percent of new bone in the bosentan 100 mg/kg group was significantly greater than that in the control group. Also, semiquantitative analysis showed higher positive vascular endothelial growth factor and osteocalcin staining and lower positive endothelin receptor type A staining in the treatment groups than in the control group. Bosentan treatment also decreased tissue endothelin 1 expression relative to that in the fracture control group. As a result of our study, the protective effect of bosentan was shown in experimental femoral fracture healing in rats by radiographic, histopathologic, and molecular analyses.
URI: http://doi.org/10.1007/s00774-014-0622-6
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2438
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