Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2388
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dc.contributor.authorBayramoglu, Adil-
dc.contributor.authorBektas, Osman-
dc.contributor.authorCelik, Abdullah-
dc.contributor.authorGunaydin, Zeki Yuksel-
dc.contributor.authorKaragoz, Ahmet-
dc.contributor.authorKaratas, Mehmet Baran-
dc.contributor.authorOzer, Fahriye Feriha-
dc.contributor.authorVural, Asli-
dc.contributor.authorYaman, Mehmet-
dc.date.accessioned2022-08-17T05:45:45Z-
dc.date.available2022-08-17T05:45:45Z-
dc.date.issued2016-
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753016/-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2388-
dc.description.abstractBackground Levodopa is the indispensable choice of medial therapy in patients with Parkinson disease (PD). Since L-dopa treatment was shown to increase serum homocysteine levels, a well-known risk factor for cardiovascular disorders, the patients with PD under L-dopa treatment will be at increased risk for future cardiovascular events. The objective of this study is to evaluate cardiovascular risk in patients with PD under levodopa treatment. Methods The study population consisted of 65 patients with idiopathic PD under L-dopa treatment. The control group included 32 age and gender matched individuals who had no cognitive decline. Echocardiographic measurements, serum homocysteine levels and elastic parameters of the aorta were compared between the patients with PD and controls. Results As an expected feature of L-dopa therapy, the Parkinson group had significantly higher homocystein levels (15.1 +/- 3.9 mu mol/L vs. 11.5 +/- 3.2 mu mol/L, P = 0.02). Aortic distensibility was significantly lower in the patients with PD when compared to controls (4.8 +/- 1.5 dyn/cm(2) vs. 6.2 +/- 1.9 dyn/cm(2), P = 0.016). Additionally, the patients with PD had higher aortic strain and aortic stiffness index (13.4% +/- 6.4% vs. 7.4% +/- 3.6%, P < 0.001 and 7.3 +/- 1.5 vs. 4.9 +/- 1.9, P < 0.001 respectively). Furthermore, serum homocysteine levels were found to be positively correlated with aortic stiffness index and there was a negative correlation between aortic distensibility and levels of serum homocysteine (r = 0.674, P < 0.001; r = -0.602, P < 0.001, respectively). Conclusions The patients with PD under L-dopa treatment have increased aortic stiffness and impaired diastolic function compared to healthy individuals. Elevated serum homocysteine levels may be a possible pathophysiological mechanism.en_US
dc.language.isoengen_US
dc.publisherSCIENCE PRESS, 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINAen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAortic distensibility; Aortic stiffness; Cardiovascular risk; Homocysteine; Parkinson diseaseen_US
dc.subjectARTERIAL STIFFNESS; DOPAMINE AGONISTS; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; ASSOCIATIONen_US
dc.titleEvaluation of cardiovascular risk in patients with Parkinson disease under levodopa treatmenten_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF GERIATRIC CARDIOLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-7578-8451en_US
dc.contributor.authorID0000-0001-9779-7578en_US
dc.contributor.authorID0000-0002-0012-2708en_US
dc.contributor.authorID0000-0002-6523-9130en_US
dc.contributor.authorID0000-0002-6616-9891en_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.startpage75en_US
dc.identifier.endpage80en_US
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