Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2338
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dc.contributor.authorEsnafoglu, Erman-
dc.contributor.authorYaman, Elif-
dc.date.accessioned2022-08-17T05:36:33Z-
dc.date.available2022-08-17T05:36:33Z-
dc.date.issued2017-
dc.identifier.urihttp://doi.org/10.1016/j.psychres.2017.04.032-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2338-
dc.description.abstractObsessive compulsive disorder (OCD) is a complex disorder with a poorly understood aetiopathogenesis. One carbon metabolism that includes vitamin B12, folic acid and homocysteine has been investigated in many psychiatric disorders like OCD. In recent years, vitamin D has also been considered to contribute to many of these psychiatric disorders. In this study we investigated whether vitamin B12, homocysteine and vitamin D play a role in the aetiology of paediatric OCD. With this aim we compared 52 children and adolescent OCD patients with 30 healthy controls. The participants were tested for vitamin B12, folic acid, homocysteine and vitamin D levels and were evaluated with a sociodemographic form, state-trait anxiety inventory 1 and 2, Kovacs Depression Inventory and Yale-Brown Obsessive Compulsive Scale (Y-BOCS). As a result we found significantly lower levels of vitamin B12 and vitamin D and higher levels of homocysteine in the patient group compared to control group (p values for all three scores were < 0.001), whereas there was no significant difference between groups in terms of folate levels (p = 0.083). This demonstrates that one carbon metabolism and vitamin D deficiency can play a role in the aetiology of OCD.en_US
dc.language.isoengen_US
dc.publisherELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELANDen_US
dc.relation.isversionof10.1016/j.psychres.2017.04.032en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectD DEFICIENCY; PLASMA HOMOCYSTEINE; FOLATE; SCHIZOPHRENIA; DEPRESSION; AUTISM; HYPERHOMOCYSTEINEMIA; NEUROTOXICITY; ASSOCIATION; PREVALENCEen_US
dc.subjectObsessive compulsive disorder; Vitamin B12; Folate; Homocysteine; Vitamin D; Aetiopathogenesisen_US
dc.titleVitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorderen_US
dc.typearticleen_US
dc.relation.journalPSYCHIATRY RESEARCHen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-8685-1153en_US
dc.identifier.volume254en_US
dc.identifier.startpage232en_US
dc.identifier.endpage237en_US
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