Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2318
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dc.contributor.authorOnder, Sevda-
dc.contributor.authorOzturk, Murat-
dc.date.accessioned2022-08-17T05:32:22Z-
dc.date.available2022-08-17T05:32:22Z-
dc.date.issued2020-
dc.identifier.urihttp://doi.org/10.1080/15569527.2020.1734815-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2318-
dc.description.abstractAim: There are reports that isotretinoin causes some important diseases such as teratogenicity, inflammatory bowel disease and sacroiliitis by triggering inflammation. (Monocyte/HDL (high density lipoprotein) ratio) MHR is closely related to inflammation and is thought to be an indicator of atherosclerotic development. We aimed to investigate how isotretinoin (ISO) affects the immunoinflammatory response in acne patients. Materials and Methods: In this study, 116 nodulocystic acne patients who received ISO treatment for at least three months were evaluated retrospectively. ISO treatment was given to patients at a dose of 0.5-1 mg/kg. Pre-treatment and post-treatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, mean platelet volume (MPV), platelet, plateletcrit, platelet distribution width (PDW), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), total cholesterol, LDL cholesterol, triglyceride, HDL cholesterol and MHR were evaluated. Results: MPV and MHR values were significantly increased after 3 month treatment (p < 0.05). There was no significant change in NLR and PLR values (p > 0.05). There was a significant decrease in neutrophil count (p < 0.05). There were no significant changes in WBC, lymphocyte, monocyte, platelet, plateletcrit values (p > 0.05). Total cholesterol, LDL cholesterol and triglyceride levels were significantly increased after three months of treatment (p < 0.05). HDL cholesterol levels decreased significantly after three months of treatment (p < 0.05). Conclusion: We concluded that ISO treatment may trigger inflammation due to the increase in MPV and MHR value. MHR can show inflammation after ISO treatment.en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLANDen_US
dc.relation.isversionof10.1080/15569527.2020.1734815en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIsotretinoin; monocyte; high density lipoprotein ratio; acne vulgarisen_US
dc.subjectMEAN PLATELET VOLUME; LYMPHOCYTE RATIO; VULGARIS; RISK; ASSOCIATION; NEUTROPHIL; DECREASESen_US
dc.titleCan monocyte/HDL show inflammatory activity of isotretinoin treatment in acne patients?en_US
dc.typearticleen_US
dc.relation.journal39en_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-4499-3724en_US
dc.identifier.volume2en_US
dc.identifier.issue111en_US
dc.identifier.startpage114en_US
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