Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2278
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dc.contributor.authorEsnafoglu, Erman-
dc.contributor.authorIrende, Ilhan-
dc.date.accessioned2022-08-17T05:26:02Z-
dc.date.available2022-08-17T05:26:02Z-
dc.date.issued2018-
dc.identifier.urihttp://doi.org/10.1007/s00702-017-1836-2-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2278-
dc.description.abstractAgmatine is a polyamine endogenously synthesized from arginine and is considered to be a new neurotransmitter. Agmatine has been implicated in the pathophysiology of several diseases such as anxiety disorder, depression, and schizophrenia. Agmatine also possesses anticonvulsant, neuroprotective, antiapoptotic, antioxidant, anxiolytic, and antidepressant effects. Furthermore, agmatine inhibits the nitric oxide synthase enzyme and exerts antagonist effects on NMDA, alpha-2, and imidazoline receptors. Considering these characteristics, the present study investigated whether agmatine plays a role in the pathogenesis of autistic spectrum disorders (ASDs). Therefore, plasma agmatine levels were evaluated in 34 patients with ASD and 28 non-ASD controls. Plasma agmatine levels were measured using the HPLC method. The study found remarkably lower agmatine levels in patients with ASD compared with the non-ASD control group (p < 0.001). These findings support the notion that agmatine might contribute to the pathogenesis of ASD and may serve as a new target for treatment.en_US
dc.language.isoengen_US
dc.publisherSPRINGER WIEN, SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIAen_US
dc.relation.isversionof10.1007/s00702-017-1836-2en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutism spectrum disorder; Autism; Agmatine; Polyamines; Pathogenesis; NMDA receptorsen_US
dc.titleDecreased plasma agmatine levels in autistic subjectsen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF NEURAL TRANSMISSIONen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-8685-1153en_US
dc.identifier.volume125en_US
dc.identifier.issue4en_US
dc.identifier.startpage735en_US
dc.identifier.endpage740en_US
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