Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2261
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dc.contributor.authorEsnafoglu, Erman-
dc.date.accessioned2022-08-17T05:23:03Z-
dc.date.available2022-08-17T05:23:03Z-
dc.date.issued2018-
dc.identifier.urihttp://doi.org/10.1016/j.jocn.2018.08.043-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2261-
dc.description.abstractThough schizophrenia and autism spectrum disorders (ASD) are separate diseases, they have some common clinical manifestations and common pathogenic mechanisms. Numerous genes are associated with these conditions. Among these genes, Neuregulin-1 forms a risk for schizophrenia and some studies have shown polymorphism of this gene accompanies schizophrenia. NRG1 has a wide variety of functions, including neuronal migration, axon guidance, synaptic transmission, oligodendroglial maturation, and neurite outgrowth. To date, NRG1 levels have not been researched in ASD patients and considering the neurodevelopmental effects of NRG1, this study aimed to research the peripheral NRG1 levels in ASD patients. The study compared 32 ASD patients and 32 healthy controls. Serum NRG-1 levels were measured with ELISA. In ASD patients (mean +/- SD, 10.80 +/- 4.78 ng/ml), the NRG1 levels were found to be statistically significantly high compared to the health control group (mean +/- SD, 6.92 +/- 4.91 ng/ml) (p = 0.004). According to the results we obtained, NRG1 was shown to play a possible role in ASD pathogenesis. There is a need for advanced studies on the possible role of NRG1 in ASD patients. This study is significant as it is the first study to measure peripheral NRG1 in ASD patients. (C) 2018 Elsevier Ltd. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDen_US
dc.relation.isversionof10.1016/j.jocn.2018.08.043en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutism spectrum disorders; Autism; Neuregulin 1; Pathogenesis; Neuregulinsen_US
dc.titleLevels of peripheral Neuregulin 1 are increased in non-medicated autism spectrum disorder patientsen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF CLINICAL NEUROSCIENCEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.identifier.volume57en_US
dc.identifier.startpage43en_US
dc.identifier.endpage45en_US
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