CHA2DS2-VASc score is a predictor of angiographic high thrombus burden in patients with ST-Segment elevation myocardial infarction

Abstract

Aim: High thrombus burden is an important indicator of complications that may occur in STEMI patients undergoing percutaneous coronary intervention. The CHA2DS2-VASc score is known as the score which is closely related to thrombosis. In this study, we aimed to investigate the association between CHA2DS2-VASc score and angiographic thrombus burden in patients with STEMI who underwent pPCI. Material and Method: A total of 570 consecutive STEMI patients who underwent pPCI were included in the study. The patients were divided into 2 groups: a high thrombus burden group and low thrombus burden group. The CHA2DS2-VASc scores were calculated for all patients. Results: The CHA2DS2-VASc scores were significantly higher in the high thrombus burden group, compared to the low thrombus burden group. Multivariate regression analysis showed that, prior MI history (odds ratio [OR] = 0.501, 95% confidence interval [CI]: 0.256-0.982, P = 0.044), history of heart failure ([OR] = 0.460, [CI]: 0.248-0.854, P = 0.014), CHA2DS2-VASc score ([OR] = 1.812, [CI]: 1.369-2.400, P < 0.001) are predictors of high thrombus burden. Receiver-operating characteristics analysis revealed the cutoff value of CHA2DS2-VASc score = 3 as a predictor of high thrombus burden with a sensitivity of 60.9% and a specificity of 75.0%. Discussion: In our study, we showed that CHA2DS2-VASc score is associated with high thrombus burden in STEMI patients who underwent primary PCI.