Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2049
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dc.contributor.authorAkcali, Aylin-
dc.contributor.authorAltunisik, Erman-
dc.contributor.authorDagli, Hasan-
dc.contributor.authorErgun, Sercan-
dc.contributor.authorGeyik, Sirma-
dc.contributor.authorKorkmaz, Murat-
dc.contributor.authorKul, Seval-
dc.contributor.authorKuzudisli, Samiye-
dc.contributor.authorNeyal, Ayse Munife-
dc.contributor.authorSensoy, Figen-
dc.contributor.authorTemiz, Ebru-
dc.date.accessioned2022-08-16T11:55:21Z-
dc.date.available2022-08-16T11:55:21Z-
dc.date.issued2016-
dc.identifier.urihttp://doi.org/10.1186/s10194-016-0623-z-
dc.identifier.urihttps://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-016-0623-z-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2049-
dc.description.abstractBackground: Urotensin-II (U-II) is a peptide recognized by its potent vasoconstrictor activity in many vascular events, however the role of urotensin-II in migraine has not been considered yet. The molecular mechanisms and genetics of migraine have not been fully clarified yet, but it is well-known that vascular changes considerably contribute in pathophysiology of migraine and also its complications. The aim of this study was to analyze the plasma U-II levels along with genotype distributions and allele frequencies for UTS2 Thr21Met and Ser89Asn polymorphisms among the patients with migraine without aura (MWoA). Methods: One hundred eighty-six patients with MWoA and 171 healthy individuals were included in this study. Plasma U-II levels were measured in attack free period. The genotype and allele frequencies for the Thr21Met (T21M) and Ser89Asn (S89N) polymorphisms in the UTS2 gene were analyzed. Results: Plasma U-II levels were significantly higher in MWoA patients (p = 0.002). We detected a significant association between the T21M polymorphism in the UTS2 gene and migraine (53.8 % in patients, 40.4 % in controls, p = 0.035), but not with S89N polymorphism (p = 0.620). A significant relationship was found between U-II levels and MIDAS score (beta = 0.508, p = 0.001). Conclusion: Our study suggests that U-II may play a role in migraine pathogenesis; also Thr21Met polymorphism was associated with the risk of migraine disease. Further studies are needed for considering the role of U-II in migraine pathophysiology and for deciding if UTS2 gene may be a novel candidate gene in migraine cases.en_US
dc.language.isoengen_US
dc.publisherSPRINGER-VERLAG ITALIA SRL, VIA DECEMBRIO, 28, MILAN, 20137, ITALYen_US
dc.relation.isversionof10.1186/s10194-016-0623-zen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraine without aura; Urotensin-2; ELISA; UTS2 gene polymorphisms; Thr21Met; Ser89Asnen_US
dc.subjectTYPE-2 DIABETES-MELLITUS; GENOME-WIDE ASSOCIATION; II RECEPTOR; RAT; RISK; PATHOPHYSIOLOGY; SUSCEPTIBILITY; LOCALIZATION; RESPONSES; JAPANESEen_US
dc.titlePlasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migrainesen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF HEADACHE AND PAINen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-6733-9848en_US
dc.identifier.volume17en_US
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