Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2017
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dc.contributor.authorAyyildiz, Ali-
dc.contributor.authorAyyildiz, Cemal-
dc.contributor.authorAyyildiz, Sema Nur-
dc.contributor.authorBenli, Erdal-
dc.contributor.authorCirakoglu, Abdullah-
dc.contributor.authorNoyan, Tevfik-
dc.date.accessioned2022-08-16T11:50:06Z-
dc.date.available2022-08-16T11:50:06Z-
dc.date.issued2017-
dc.identifier.urihttp://doi.org/10.1515/tjb-2016-0271-
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/tjb-2016-0271/html-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2017-
dc.description.abstractIntroduction: Prostate specific antigen (PSA) has a lower sensitivity and specifity range of 4-10 ng/mL. We aimed to investigate the effectiveness of pPSA in reducing number of prostate biopsies. Methods: This study enrolled 80 patients aged 50 years or older whom had serum total PSA levels between 4 ng/dL and 10 ng/dL. Age, prostate volume, tPSA, fPSA, pPSA, PSA%, pPSA%, t/pPSA, f/pPSA, p/fPSA, p/tPSA, f/p/tPSA, p/f/tPSA, PSAD, fPSA/PSAD, pPSA/PSAD, (Prostate Health Index) PHI, (t/f/pPSA)/tPSA, and PHI2 (New Prostate Health Index) biopsy results were compared between subjects BPH and PCa. Results: Out of 80 subjects, 23 (29%) had PCa and 57 (71%) had BPH. Prostate volume was 51.65 mL in PCa and 64.85 mL in non-PCa group (p > 0.05). The rate of PCa increased as prostate volume was reduced and age increased. fPSA, PSA%, p/f/tPSA, fPSA/PSAD values were significant in favor of respectively; BPH, BPH, PCa and BPH (p < 0.05). Discussion: Using prostate health index (PHI) was beneficial for predicting PCa. In addition, using pPSA in formulas such as (PHI2) pPSA/(fPSA*v tPSA), p/f/tPSA, (t/f/pPSA)/tPSA may also be useful. This study suggests that the use of pPSA may have a role in reducing the number of prostate biopsies in differentiating PCa and BPH.en_US
dc.language.isoengen_US
dc.publisherWALTER DE GRUYTER GMBH, GENTHINER STRASSE 13, D-10785 BERLIN, GERMANYen_US
dc.relation.isversionof10.1515/tjb-2016-0271en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPROPROSTATE-SPECIFIC ANTIGEN; HEALTH INDEX; 10.0 NG/ML; CANCER; MULTICENTER; RANGE; PREDICTION; IMPROVE; MENen_US
dc.subjectProstate cancer; Prostate biopsy; PSA; proPSA; Prostate health indexen_US
dc.titleSerum proPSA as a marker for reducing repeated prostate biopsy numbersen_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-8485-1424en_US
dc.contributor.authorID0000-0002-7733-0177en_US
dc.contributor.authorID0000-0002-8602-5836en_US
dc.identifier.volume42en_US
dc.identifier.issue1en_US
dc.identifier.startpage65en_US
dc.identifier.endpage69en_US
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