Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1938
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dc.contributor.authorAltay, Diler Us-
dc.contributor.authorDemir, Selim-
dc.contributor.authorKaraguzel, Ersagun-
dc.contributor.authorKazaz, Ilke O.-
dc.contributor.authorMentese, Ahmet-
dc.contributor.authorOkatan, Ali Ertan-
dc.contributor.authorOrem, Asim-
dc.contributor.authorYaman, Serap Ozer-
dc.date.accessioned2022-08-16T11:30:36Z-
dc.date.available2022-08-16T11:30:36Z-
dc.date.issued2017-
dc.identifier.urihttp://doi.org/10.1590/S1677-5538.IBJU.2016.0316-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1938-
dc.description.abstractPurpose: To investigate the efficacy of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) as a novel biomarker of renal tumors. Materials and Methods: 48 individuals were included in the study. The patient group (Group-1) consisted of 23 subjects diagnosed with renal tumor, and the control group (Group-2) of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected following overnight fasting. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1), soluble urokinase plasminogen activator receptor (suPAR) and carbonic anhydrase IX (CA IX) levels were measured from plasma samples. Patients in groups 1 and 2 were compared in terms of these biochemical parameters. Results: The 23-member renal tumor group was made up of 17 (73.91%) male and 6 (26.08%) female patients with a mean age of 58.5 +/- 15.7 years (range 25 to 80). The 24-member healthy control group was made up of 16 (64%) male and 9 (36%) female subjects with a mean age of 52.4 +/- 9.12 years (range 40 to 67). Analysis revealed significant elevation in SCUBE-1 levels in the renal tumor group (p=0.005). No significant differences were detected between the groups with regard to CA IX or suPAR measurements (p=0.062 vs. p=0.176). Conclusions: SCUBE-1 appears to represent a promising biomarker in the diagnosis and follow-up of patients with renal tumor.en_US
dc.language.isoengen_US
dc.publisherBRAZILIAN SOC UROL, RUA BAMBINA, 153, RIO DE JANEIRO, 2251-050, BRAZILen_US
dc.relation.isversionof10.1590/S1677-5538.IBJU.2016.0316en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCARBONIC-ANHYDRASE-IX; PLASMINOGEN-ACTIVATOR RECEPTOR; DOMAIN-CONTAINING PROTEIN-1; INDEPENDENT PREDICTOR; SERUM-LEVELS; CARCINOMA; DIAGNOSIS; DISEASE; SURFACE; SYSTEMen_US
dc.subjectCarcinoma; Renal Cell; Biomarkersen_US
dc.titleSCUBE1: a promising biomarker in renal cell canceren_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL BRAZ J UROLen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-0465-8403en_US
dc.contributor.authorID0000-0002-1863-6280en_US
dc.identifier.volume43en_US
dc.identifier.issue4en_US
dc.identifier.startpage638en_US
dc.identifier.endpage643en_US
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