Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1673
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dc.contributor.authorAvci, Bahattin-
dc.contributor.authorCanakci, Varol-
dc.contributor.authorCelen, Selman-
dc.contributor.authorDede, Figen Ongoz-
dc.contributor.authorDeveci, Emre Taha-
dc.contributor.authorGokmenoglu, Ceren-
dc.contributor.authorKara, Cankat-
dc.date.accessioned2022-08-16T05:59:35Z-
dc.date.available2022-08-16T05:59:35Z-
dc.date.issued2020-
dc.identifier.urihttp://doi.org/10.1111/jre.12796-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1673-
dc.description.abstractBackground and Objective Interleukin (IL)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms. The aim of this study was to investigate the levels of IL-32 alpha, IL-32 beta, IL-32 gamma, IL-32 delta isoforms in gingival crevicular fluid (GCF) and plasma before and after non-surgical periodontal treatment in patients with periodontitis (P). Materials and Methods Twenty-seven P and 27 periodontally healthy controls (C) were recruited in this study. Non-surgical periodontal treatment was performed to periodontitis patients. GCF and plasma sampling and clinical periodontal parameters were evaluated before and 1 month after treatment. Enzyme-linked immunosorbent assay was used to analyze the levels of IL-32 alpha, IL-32 beta, IL-32 gamma, IL-32 delta isoforms in GCF and plasma samples. Results The levels of IL-32 alpha, IL-32 beta, IL-32 gamma, and IL-32 delta in plasma and GCF were significantly higher in patients with periodontitis than healthy controls (P < .001). In P group, plasma and GCF IL-32 alpha, IL-32 beta, IL-32 gamma, and IL-32 delta levels after non-surgical periodontal treatment were lower when compared to baseline (P < .001). Moreover, there was a positive correlation between GCF and plasma IL-32 alpha, IL-32 beta, IL-32 gamma, and IL-32 delta levels in all groups at baseline and after treatment (P < .05). Conclusion The study supported that there was a relationship between elevated levels of IL-32 isoforms and periodontitis. Also, our novel findings suggest that the pro-inflammatory role of IL-32 in the periodontitis may be originated from IL-32 alpha, IL-32 beta, IL-32 gamma, and IL-32 delta isoforms.en_US
dc.language.isoengen_US
dc.publisherWILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USAen_US
dc.relation.isversionof10.1111/jre.12796en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgingival crevicular fluid; IL-32 isoforms; interleukin-32; periodontitis; plasmaen_US
dc.subjectPERI-IMPLANT DISEASES; CLASSIFICATION; EXPRESSIONen_US
dc.titleIncreased levels of interleukin-32 isoforms alpha, beta, gamma, and delta in the gingival crevicular fluid and plasma of the patients with periodontitisen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF PERIODONTAL RESEARCHen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-6471-6495en_US
dc.contributor.authorID0000-0002-3803-7189en_US
dc.contributor.authorID0000-0002-4211-3359en_US
dc.contributor.authorID0000-0003-2983-8758en_US
dc.identifier.volume56en_US
dc.identifier.issue1en_US
dc.identifier.startpage83en_US
dc.identifier.endpage92en_US
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