Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1503
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dc.contributor.authorBishehsari, Faraz-
dc.contributor.authorEngen, Phillip A.-
dc.contributor.authorForsyth, Christopher B.-
dc.contributor.authorGreen, Stefan J.-
dc.contributor.authorHamaker, Bruce R.-
dc.contributor.authorKeshavarzian, Ali-
dc.contributor.authorKhazaie, Khashayarsha-
dc.contributor.authorNaqib, Ankur-
dc.contributor.authorPreite, Nailliw Z.-
dc.contributor.authorRossi, Marco-
dc.contributor.authorShaikh, Maliha-
dc.contributor.authorTuncil, Yunus E.-
dc.contributor.authorVoigt, Robin M.-
dc.contributor.authorWilber, Sherry-
dc.date.accessioned2022-08-16T05:12:37Z-
dc.date.available2022-08-16T05:12:37Z-
dc.date.issued2018-
dc.identifier.urihttp://doi.org/10.3390/genes9020102-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1503-
dc.description.abstractEpidemiological studies propose a protective role for dietary fiber in colon cancer (CRC). One possible mechanism of fiber is its fermentation property in the gut and ability to change microbiota composition and function. Here, we investigate the role of a dietary fiber mixture in polyposis and elucidate potential mechanisms using TS4Cre x cAPC(l)degrees(x468) mice. Stool microbiota profiling was performed, while functional prediction was done using PICRUSt. Stool short-chain fatty acid (SCFA) metabolites were measured. Histone acetylation and expression of SCFA butyrate receptor were assessed. We found that SCFA-producing bacteria were lower in the polyposis mice, suggesting a decline in the fermentation product of dietary fibers with polyposis. Next, a high fiber diet was given to polyposis mice, which significantly increased SCFA-producing bacteria as well as SCFA levels. This was associated with an increase in SCFA butyrate receptor and a significant decrease in polyposis. In conclusion, we found polyposis to be associated with dysbiotic microbiota characterized by a decline in SCFA-producing bacteria, which was targetable by high fiber treatment, leading to an increase in SCFA levels and amelioration of polyposis. The prebiotic activity of fiber, promoting beneficial bacteria, could be the key mechanism for the protective effects of fiber on colon carcinogenesis. SCFA-promoting fermentable fibers are a promising dietary intervention to prevent CRC.en_US
dc.language.isoengen_US
dc.publisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLANDen_US
dc.relation.isversionof10.3390/genes9020102en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCRC; dietary fiber; microbiota; SCFA; butyrateen_US
dc.titleDietary Fiber Treatment Corrects the Composition of Gut Microbiota, Promotes SCFA Production, and Suppresses Colon Carcinogenesisen_US
dc.typearticleen_US
dc.relation.journalGENESen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-5644-2586en_US
dc.contributor.authorID0000-0002-0675-9080en_US
dc.contributor.authorID0000-0002-9421-2332en_US
dc.contributor.authorID0000-0002-9421-2332en_US
dc.contributor.authorID0000-0003-2781-359Xen_US
dc.identifier.volume9en_US
dc.identifier.issue2en_US
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